PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases
In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs).The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation.Promyelocytic leukemia protein (PML), a major component of nuclear bodies, jumbo gourmet tava and mSin